Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEplivanserin hemifumarate
说明： Potent and selective 5-HT2A antagonist
别名： SR-46349 hemifumarate,SR-46349B
化学名： (1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate
纯度： ≥98% (HPLC)
生物活性 for Eplivanserin hemifumarate
Eplivanserin hemifumarate is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.
技术数据 for Eplivanserin hemifumarate
| 分子量 | 386.42 |
| 公式 | C19H21FN2O2.0.5C4H4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 130580-02-8 |
| PubChem ID | 6438382 |
| InChI Key | UCLIFEBROADCQW-PWERMGERSA-N |
| Smiles | OC(C=C2)=CC=C2/C=C/C(C1=CC=CC=C1F)=N/OCCN(C)C.O=C(/C=C/C(O)=O)O.OC(C=C4)=CC=C4/C=C/C(C3=CC=CC=C3F)=N/OCCN(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Eplivanserin hemifumarate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 19.32 | 50 |
制备储备液 for Eplivanserin hemifumarate
以下数据基于产品分子量 386.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.18 mL | 25.88 mL | 51.76 mL |
| 2.5 mM | 1.04 mL | 5.18 mL | 10.35 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.18 mL |
| 25 mM | 0.1 mL | 0.52 mL | 1.04 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Eplivanserin hemifumarate
参考文献 for Eplivanserin hemifumarate
参考文献是支持产品生物活性的出版物。
Yadav et al (2011) Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo. J.Pharmacol.Exp.Ther. 339 99 PMID: 21737536
Filip et al (2004) Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J.Pharmacol.Exp.Ther. 310 1246 PMID: 15131246
Bonaccorso et al (2002) SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced DA release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology. 27 430 PMID: 12225700
If you know of a relevant reference for Eplivanserin hemifumarate, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Eplivanserin hemifumarate, Eplivanserin hemifumarate supplier, antipsychotic, potent, selective, 5-HT2A, antagonist, SR-46349, hemifumarate, SR-46349B, Receptors, 4958, Tocris Bioscience
篇 Eplivanserin hemifumarate 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 Eplivanserin hemifumarate 的引用文献。 您是否知道使用了 Tocris Eplivanserin hemifumarate 的优秀论文？ 请告知我们.
Eplivanserin hemifumarate 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Eplivanserin hemifumarate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Eplivanserin hemifumarate blocks MDMA-induced striatal activation and locomotion.
By
Kevin Ball on 01/25/2019
分析类型： In Vivo
种属： Rat
We assessed the effect of the 5-HT2A antagonist, SR-46349B (eplivanserin hemifumarate; 0.5 mg/kg, s.c.), on MDMA (ecstasy)-induced locomotion and dorsal striatal single-unit electrophysiology. SR-46349B blocked nearly all MDMA-induced striatal excitations, which paralleled its significant attenuation of MDMA-induced locomotor activation (shown in figure).
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.