ERB 041

Cat. No. 4276 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent ERβ agonist

化学名： 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol

纯度： ≥98% (HPLC)

引用文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ERB 041

ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC₅₀ values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for ERB 041

分子量	271.24
公式	C₁₅H₁₀FNO₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	524684-52-4
PubChem ID	5326893
InChI Key	FCXYSEXZEGPLGG-DHDCSXOGSA-N
Smiles	C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ERB 041

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	27.12	100
	ethanol	27.12	100

制备储备液 for ERB 041

以下数据基于产品分子量 271.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.87 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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产品说明书 for ERB 041

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ERB 041

参考文献是支持产品生物活性的出版物。

Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241 PMID: 14500559

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246

Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630 PMID: 18097065

If you know of a relevant reference for ERB 041, please let us know.

按标靶查看相关产品

Estrogen and Related Receptors

关键词: ERB 041, ERB 041 supplier, pfizer, ERB041, potent, erb, erbeta, erγ, estrogen, receptors, agonists, selective, Estrogen, and, Related, Receptors, 4276, Tocris Bioscience

2 篇 ERB 041 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ERB 041 的部分引用包括：

Gang et al (2021) Estrogen Receptor β Contributes to Both Hypertension and Hypothalamic Plasticity in a Mouse Model of Peri-Menopause. J Neurosci 41 5190-5205 PMID: 33941651

Cortes et al (2018) GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. e46556 PMID: 30538117

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Pathways for ERB 041

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.