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Submit ReviewES 936
说明： Mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase (NQO1)
化学名： 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenyoxy)methyl]-1H-indole
纯度： ≥98% (HPLC)
生物活性 for ES 936
Mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase (NQO1). Induces growth inhibition in human pancreatic carcinoma (MIA PaCa-2) and adenocarcinoma (BxPC-3) cell lines with IC50 values of 108 and 365 nM respectively. Also inhibits TNF-α-induced E-selectin protein expression in human bone marrow endothelial cells. Exhibits no effects on other cellular reductases or levels of acid-soluble thiols.
技术数据 for ES 936
| 分子量 | 356.33 |
| 公式 | C18H16N2O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 192820-78-3 |
| Smiles | O=C(C=C1OC)C2=C(C(COC3=CC=C([N+]([O-])=O)C=C3)=C(C)N2C)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ES 936
参考文献 for ES 936
参考文献是支持产品生物活性的出版物。
Dehn et al (2006) 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol.Cancer Ther. 5 1702 PMID: 16891456
Dehn et al (2003) Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems. Mol.Pharmacol. 64 714 PMID: 12920209
Zhou et al (2010) NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34 hematopoietic cell adhesion. J.Pharm.Exp.Ther. 334 260 PMID: 20378716
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关键词: ES 936, ES 936 supplier, ES936, mechanism-based, inhibitor, NADPH, quinone, oxidoreductase, NQO1, inhibitors, inhibits, NADH, Other, Reductase, 4022, Tocris Bioscience
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