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ET 18-OCH3

Cat. No. 7462 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective PI-PLC inhibitor, also PAF receptor agonist
化学名： 4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium 4-oxide
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ET 18-OCH3

ET 18-OCH3 is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells). ET 18-OCH3 acts as an agonist at platelet-activating factor (PAF) receptors. ET 18-OCH3 is an antitumor lipid that selectively induces apoptosis in tumor cells, sparing normal cells, and activates the intracellular Fas/CD95 death receptor. ETH 18-OCH3 also triggers eryptosis and interacts with mitochondrial membranes to increase mitochondrial membrane permeability, leading to dysfunction and apoptosis. Racemic mixture.

技术数据 for ET 18-OCH3

分子量 523.73
公式 C27H58NO6P
储存 Store at -20°C
CAS Number 70641-51-9
PubChem ID 1392
InChI Key MHFRGQHAERHWKZ-UHFFFAOYSA-N
Smiles COC(COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ET 18-OCH3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 10.47 20

制备储备液 for ET 18-OCH3

以下数据基于产品分子量 523.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.55 mL 47.73 mL 95.47 mL
1 mM 1.91 mL 9.55 mL 19.09 mL
2 mM 0.95 mL 4.77 mL 9.55 mL
10 mM 0.19 mL 0.95 mL 1.91 mL

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参考文献 for ET 18-OCH3

参考文献是支持产品生物活性的出版物。

Mollinedo et al (2004) ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr.Med.Chem. 11 3163 PMID: 15579006

Briglia et al (2015) Edelfosine induced suicidal death of human erythrocytes. Cell.Physiol.Biochem. 37 2221 PMID: 26618532

Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835 PMID: 1316230

Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225 PMID: 7594622

Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138 PMID: 17628524

Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15 PMID: 17509155

If you know of a relevant reference for ET 18-OCH3, please let us know.

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关键词: ET 18-OCH3, ET 18-OCH3 supplier, ET18-OCH3, Edelfosine, Selective, PI-PLC, inhibitors, inhibits, PAF, Phospholipases, phospholipaseC, Phosphoinositide-Specific, Esterases, Platelet-activating, Factor, Receptors, ET18OCH3, ET-18-OCH3, phospholipid, lysophospholipid, apoptosis, eryptosis, (PAF), Phospholipase, C, 7462, Tocris Bioscience

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