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Ethyl LipotF

Cat. No. 5950 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective FTO inhibitor
化学名： Ethyl (E)-4-(2-(4-benzylnicotinoyl)hydrazinyl)-4-oxobut-2-enoate
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ethyl LipotF

Ethyl LipotF is a selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner.

技术数据 for Ethyl LipotF

分子量 353.38
公式 C19H19N3O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1808089-27-1
InChI Key XUKLGMSFWAEOPR-CMDGGOBGSA-N
Smiles O=C(NNC(/C=C/C(OCC)=O)=O)C1=C(CC2=CC=CC=C2)C=CN=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ethyl LipotF

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 7.07 20
DMSO 35.34 100

制备储备液 for Ethyl LipotF

以下数据基于产品分子量 353.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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参考文献 for Ethyl LipotF

参考文献是支持产品生物活性的出版物。

Toh et al (2015) A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO. Chem.Sci. 6 112 PMID: 28553460

Cheong et al (2018) A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells. Chem.Sci. 9 7174 PMID: 30288236

If you know of a relevant reference for Ethyl LipotF, please let us know.

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关键词: Ethyl LipotF, Ethyl LipotF supplier, FTO, inhibitors, inhibits, fat, mass, and, obesity, associated, protein, mRNA, N6-methyladenine, demethylase, ALKBH9, α, alpha-ketoglutarate-dependent, dioxygenase, M6A, Other, Oxygenases/Oxidases, 5950, Tocris Bioscience

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