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Etomidate

Cat. No. 1471 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
化学名： (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Etomidate

Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.

技术数据 for Etomidate

分子量 244.29
公式 C14H16N2O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 33125-97-2
PubChem ID 667484
InChI Key NPUKDXXFDDZOKR-LLVKDONJSA-N
Smiles O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Etomidate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 24.43 100
1eq. HCl 12.21 50

制备储备液 for Etomidate

以下数据基于产品分子量 244.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.93 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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参考文献 for Etomidate

参考文献是支持产品生物活性的出版物。

Belelli et al (1997) The interaction of the general anesthetic EtoM. with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 94 11031 PMID: 9380754

Giese et al (1983) EtoM.: a new intravenous anesthetic induction agent. Pharmacother. 3 251 PMID: 6359080

Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic EtoM. at GABAA receptors. Toxicol.Lett. 100-101 209 PMID: 10049144

If you know of a relevant reference for Etomidate, please let us know.

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关键词: Etomidate, Etomidate supplier, GABA, mimetic, modulatory, agent, GABAA, Receptors, 1471, Tocris Bioscience

3 篇 Etomidate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Etomidate 的部分引用包括：

Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol 150 305 PMID: 29454619

Rodgers et al (2015) EtoM. Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. Proc Natl Acad Sci U S A 35 9707 PMID: 26134653

Drasbek et al (2007) Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex. J Neurophysiol 97 2293 PMID: 17215511

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Etomidate 的评论

平均评分: 5 (Based on 1 Review.)

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Would purchase again.
By Anonymous on 07/27/2022
分析类型： In Vivo
种属： Mouse

We purchased this product and used it as anesthesia.

It came on time, amount was accurate. We would purchase again.

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