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Submit ReviewFamotidine
说明： Potent and high affinity H2 biased inverse agonist
化学名： 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
纯度： ≥98% (HPLC)
生物活性 for Famotidine
Famotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.
技术数据 for Famotidine
| 分子量 | 337.44 |
| 公式 | C8H15N7O2S3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 76824-35-6 |
| PubChem ID | 3325 |
| InChI Key | XUFQPHANEAPEMJ-UHFFFAOYSA-N |
| Smiles | NC(=N)NC1=NC(CSCCC(=N)N[S](N)(=O)=O)=CS1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Famotidine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.74 | 100 |
制备储备液 for Famotidine
以下数据基于产品分子量 337.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.63 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for Famotidine
参考文献 for Famotidine
参考文献是支持产品生物活性的出版物。
Takagi et al (1982) Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch.Int.Pharmacodyn.Ther. 256 49 PMID: 6124219
Pendleton et al (1985) Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J.Pharmacol.Exp.Ther. 233 64 PMID: 2858583
Bourinbaiar & Fruhstorfer (1996) The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents. Life Sci. 59 365 PMID: 8950301
Malone et al (2020) COVID-19: Famotidine, histamine, mast cells, and mechanisms. Res.Sq. - Paper not yet peer reviewed PMID: 32702719
If you know of a relevant reference for Famotidine, please let us know.
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关键词: Famotidine, Famotidine supplier, YM, 11170, MK, 208, histamine, h2, receptor, inverse, agonists, antagonists, biased, signaling, antiviral, COVID-19, mast, cell, activation, Histamine, H2, Receptors, HIV, 7290, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.