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Famotidine

Cat. No. 7290 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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7290 has been discontinued.

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说明： Potent and high affinity H2 biased inverse agonist
化学名： 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Famotidine

Famotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.

技术数据 for Famotidine

分子量 337.44
公式 C8H15N7O2S3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 76824-35-6
PubChem ID 3325
InChI Key XUFQPHANEAPEMJ-UHFFFAOYSA-N
Smiles NC(=N)NC1=NC(CSCCC(=N)N[S](N)(=O)=O)=CS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Famotidine

参考文献是支持产品生物活性的出版物。

Takagi et al (1982) Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch.Int.Pharmacodyn.Ther. 256 49 PMID: 6124219

Pendleton et al (1985) Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J.Pharmacol.Exp.Ther. 233 64 PMID: 2858583

Bourinbaiar & Fruhstorfer (1996) The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents. Life Sci. 59 365 PMID: 8950301

Malone et al (2020) COVID-19: Famotidine, histamine, mast cells, and mechanisms. Res.Sq. - Paper not yet peer reviewed PMID: 32702719

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关键词: Famotidine, Famotidine supplier, YM, 11170, MK, 208, histamine, h2, receptor, inverse, agonists, antagonists, biased, signaling, antiviral, COVID-19, mast, cell, activation, Histamine, H2, Receptors, HIV, 7290, Tocris Bioscience

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Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.