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Submit ReviewFananserin
说明： 5-HT2A antagonist; also D4 antagonist
别名： RP 62203
化学名： 2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide
纯度： ≥99% (HPLC)
生物活性 for Fananserin
Fananserin is a 5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1, α1, 5-HT1A and D2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo.
技术数据 for Fananserin
| 分子量 | 425.52 |
| 公式 | C23H24FN3O2S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 127625-29-0 |
| PubChem ID | 60785 |
| InChI Key | VGIGHGMPMUCLIQ-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(C=C1)N1CCN(CCCN2C3=C4C(=CC=CC4=CC=C3)S2(=O)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Fananserin
参考文献 for Fananserin
参考文献是支持产品生物活性的出版物。
Malleron et al (1991) Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. J.Med.Chem. 34 2477 PMID: 1908521
Doble et al (1992) Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist. Br.J.Pharmacol. 105 27 PMID: 1596688
Heuillet et al (1996) The naphtosultam derivative RP 62203 (fananserin) has high affinity for the DA D4 receptor. Eur.J.Pharmacol. 314 229 PMID: 8957240
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关键词: Fananserin, Fananserin supplier, 5-HT2A, antagonists, D4, Serotonin, Receptors, Dopamine, dopaminergic, RP62203, RP, 62203, 2645, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.