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Submit ReviewFC 131
说明： CXCR4 antagonist
生物活性 for FC 131
CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
技术数据 for FC 131
| 分子量 | 729.84 |
| 公式 | C36H47N11O6 |
| 序列 | XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr] |
| 储存 | Store at -20°C |
| CAS Number | 606968-52-9 |
| PubChem ID | 5275848 |
| InChI Key | MBXBICVKLVYNKD-QUAHOIDUSA-N |
| Smiles | NC(=N)NCCC[C@@H]1NC(=O)[C@@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CCCNC(N)=N)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FC 131
参考文献 for FC 131
参考文献是支持产品生物活性的出版物。
Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380 PMID: 15658852
Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477
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关键词: FC 131, FC 131 supplier, FC131, cxcr4, antagonists, chemokines, receptors, anti-HIV, Chemokine, CXC, Receptors, HIV, 4320, Tocris Bioscience
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