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Submit ReviewFenretinide
说明： Synthetic retinoid; antiproliferative and antioxidant
别名： 4-HPR
化学名： N-(4-Hydroxyphenyl)retinamide
纯度： ≥98% (HPLC)
生物活性 for Fenretinide
Fenretinide is a synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
技术数据 for Fenretinide
| 分子量 | 391.55 |
| 公式 | C26H33NO2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 65646-68-6 |
| PubChem ID | 5288209 |
| InChI Key | AKJHMTWEGVYYSE-FXILSDISSA-N |
| Smiles | CC(/C=C/C1=C(C)CCCC1(C)C)=C\C=C\C(C)=C\C(=O)NC1=CC=C(O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Fenretinide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 39.16 | 100 | |
| DMSO | 39.16 | 100 |
制备储备液 for Fenretinide
以下数据基于产品分子量 391.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.77 mL | 25.54 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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产品说明书 for Fenretinide
参考文献 for Fenretinide
参考文献是支持产品生物活性的出版物。
Le Doze et al (2000) Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat. Drug Metab.Dispos. 28 205 PMID: 10640519
Takahashi (2000) Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide). Biol.Pharm.Bull. 23 222 PMID: 10706389
Ulukaya and Wood (1999) Fenretinide and its relation to cancer. Cancer Treat.Rev. 25 229 PMID: 10448131
If you know of a relevant reference for Fenretinide, please let us know.
关键词: Fenretinide, Fenretinide supplier, Synthetic, retinoid, agonists, Potent, anti-cancer, agent, RXR, Retinoid, X, Receptors, RAR, RAMBA, Retinoic, Acid, 4-HPR, Receptor, 1396, Tocris Bioscience
6 篇 Fenretinide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Fenretinide 的部分引用包括：
Seidensaal et al (2015) Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma. Am J Pathol 14 204 PMID: 26634247
Jung et al (2017) Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. EMBO Rep 18 1150 PMID: 28507162
Xie et al (2019) Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal. Cell Stem Cell 25 639 PMID: 31631013
Catanese et al (2019) Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation. Autophagy 15 1719 PMID: 30939964
Lancaster et al (2018) Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism. Cell Metab 27 1096 PMID: 29681442
Johansson et al (2013) Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer. Nat Commun 4 2175 PMID: 23868472
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Fenretinide 的评论
平均评分: 5 (Based on 1 Review.)
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Fenretinide was tested to understand its induction of apoptotic cell death in B-cell non-Hodgkin lymphoma.
By
Anonymous on 12/23/2019
种属： Human
Fenretinide was tested to understand its induction of apoptotic cell death in B-cell non-Hodgkin lymphoma (NHL).
Fenretinide at 900 mg/m2 PO BID for days 1–5 of a 7-day cycle used.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.