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说明： Potent, specific ligand for mitochondrial DBI receptor
化学名： N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
纯度： ≥98% (HPLC)
生物活性 for FGIN-1-27
Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.
技术数据 for FGIN-1-27
| 分子量 | 436.61 |
| 公式 | C28H37FN2O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 142720-24-9 |
| PubChem ID | 132496 |
| InChI Key | VUWXAQFLTSBUDB-UHFFFAOYSA-N |
| Smiles | O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FGIN-1-27
参考文献 for FGIN-1-27
参考文献是支持产品生物活性的出版物。
Romeo et al (1992) 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 262 971 PMID: 1326631
Kozikowski et al (1992) Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation. Angew.Chem.Int.Ed. 31 1060
关键词: FGIN-1-27, FGIN-1-27 supplier, Potent, specific, ligand, mitochondrial, DBI, receptor, GABAA, Receptors, FGIN127, Translocator, Protein, 0658, Tocris Bioscience
1 篇 FGIN-1-27 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FGIN-1-27 的部分引用包括：
Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Glia 89 564 PMID: 12888831
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