FICZ

Cat. No. 5304 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity aryl hydrocarbon receptor (AhR) agonist

化学名： 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde

纯度： ≥95% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for FICZ

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (K_d = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

技术数据 for FICZ

分子量	284.31
公式	C₁₉H₁₂N₂O
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	172922-91-7
PubChem ID	1863
InChI Key	ZUDXFBWDXVNRKF-UHFFFAOYSA-N
Smiles	[H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FICZ

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	7.11	25

制备储备液 for FICZ

以下数据基于产品分子量 284.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	14.07 mL	70.35 mL	140.69 mL
1.25 mM	2.81 mL	14.07 mL	28.14 mL
2.5 mM	1.41 mL	7.03 mL	14.07 mL
12.5 mM	0.28 mL	1.41 mL	2.81 mL

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产品说明书 for FICZ

分析证书/产品说明书

化学品安全技术说明书

参考文献 for FICZ

参考文献是支持产品生物活性的出版物。

Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817

Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769

Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038

If you know of a relevant reference for FICZ, please let us know.

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