Finasteride

Cat. No. 3293 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Type II 5α-reductase inhibitor

别名： MK 906

化学名： (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

纯度： ≥99% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Finasteride

Finasteride is an antiandrogen that inhibits type II 5α reductase (IC₅₀ = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.

技术数据 for Finasteride

分子量	372.54
公式	C₂₃H₃₆N₂O₂
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	98319-26-7
PubChem ID	57363
InChI Key	DBEPLOCGEIEOCV-WSBQPABSSA-N
Smiles	C[C@@]12[C@](CC[C@@H]2C(NC(C)(C)C)=O)([H])[C@]3([H])CC[C@@]4([H])NC(C=C[C@]4(C)[C@@]3([H])CC1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Finasteride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	37.25	100
	ethanol	37.25	100

制备储备液 for Finasteride

以下数据基于产品分子量 372.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.42 mL	26.84 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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产品说明书 for Finasteride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Finasteride

参考文献是支持产品生物活性的出版物。

Thigpen and Russell (1992) Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 267 8577 PMID: 1314830

Gao et al (2004) Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145 5420 PMID: 15308613

Mukai et al (2008) Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 31 1646 PMID: 18758053

If you know of a relevant reference for Finasteride, please let us know.

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关键词: Finasteride, Finasteride supplier, Type, II, 5α-reductases, 5alpha-reductases, inhibitors, inhibits, MK906, MK, 906, Other, Reductase, Androgen, Receptor, 3293, Tocris Bioscience

2 篇 Finasteride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Finasteride 的部分引用包括：

Handa et al (2013) Central 5-α reduction of testost. is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats. Nat Neurosci 1529 74 PMID: 23880372

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647

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