Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFisetin
说明： Naturally occuring flavonoid and antioxidant; neuroprotective
化学名： 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
纯度： ≥97% (HPLC)
生物活性 for Fisetin
Fisetin is a naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.
技术数据 for Fisetin
| 分子量 | 286.24 |
| 公式 | C15H10O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 528-48-3 |
| PubChem ID | 5281614 |
| InChI Key | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
| Smiles | OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Fisetin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.62 | 100 | |
| ethanol | 2.86 | 10 |
制备储备液 for Fisetin
以下数据基于产品分子量 286.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.49 mL | 17.47 mL | 34.94 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.99 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.49 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Fisetin
参考文献 for Fisetin
参考文献是支持产品生物活性的出版物。
Lu et al (2005) Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 48 737 PMID: 15689157
Adhami et al (2012) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 84 1277 PMID: 22842629
Haddad et al (2010) Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 62 668 PMID: 20574928
Maher et al (2011) ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 20 261 PMID: 20952447
Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419
If you know of a relevant reference for Fisetin, please let us know.
关键词: Fisetin, Fisetin supplier, flavonoids, antioxidants, inhibitors, inhibits, PI, 3-K, kinase, Akt, mTOR, Cdk6, antiproliferative, cancer, activates, ERK, neuroprotective, Huntington's, DNA, Methyltransferases, DNMT, Antioxidants, 5016, Tocris Bioscience
4 篇 Fisetin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Fisetin 的部分引用包括：
Alun M et al (2021) How CD40L reverse signaling regulates axon and dendrite growth. Cell Mol Life Sci 78 1065-1083 PMID: 32506167
Alun M et al (2021) Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth. Cells 10 PMID: 33917019
Young Ho et al (2021) A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway. Sci Rep 11 21119 PMID: 34702966
Kim et al (2016) Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. PLoS Pathog 6 24933 PMID: 27112200
您是否知道使用了 Tocris Fisetin 的优秀论文？ 请告知我们.
Fisetin 的评论
目前没有该产品的评论。 Be the first to review Fisetin and earn rewards!
Have you used Fisetin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image