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Discontinued Product
1480 has been discontinued.
说明： Irreversible δ agonist
别名： Fentanyl isothiocyanate
化学名： N-[1-[2-(4-Isothiocyanatophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide
纯度： ≥99% (HPLC)
生物活性 for FIT
Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.
技术数据 for FIT
| 分子量 | 393.55 |
| 公式 | C23H27N3OS |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 85951-63-9 |
| PubChem ID | 84008 |
| InChI Key | VDKBIFPJULZUPU-UHFFFAOYSA-N |
| Smiles | CCC(=O)N(C1CCN(CCC2=CC=C(C=C2)N=C=S)CC1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FIT
参考文献 for FIT
参考文献是支持产品生物活性的出版物。
Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314 PMID: 6132444
Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227 PMID: 2991807
Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fen. isothiocyanate. Eur.J.Pharmacol. 154 169 PMID: 2906610
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关键词: FIT, FIT supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Fentanyl, isothiocyanate, Delta, Opioid, 1480, Tocris Bioscience
1 篇 FIT 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FIT 的部分引用包括：
Gross et al (2006) The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291 H827 PMID: 16517948
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.