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说明： Inhibitor of Notch signaling; disrupts Notch trafficking and processing
化学名： Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
纯度： ≥99% (HPLC)
生物活性 for FLI 06
FLI 06 is an inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
技术数据 for FLI 06
| 分子量 | 438.52 |
| 公式 | C25H30N2O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 313967-18-9 |
| PubChem ID | 3103157 |
| InChI Key | SWWVFYHSSOWZMF-UHFFFAOYSA-N |
| Smiles | O=C(OC3CCCCC3)C1=C(C)NC(CC(C)(C)CC4=O)=C4C1C2=CC=C([N+]([O-])=O)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FLI 06
参考文献 for FLI 06
参考文献是支持产品生物活性的出版物。
Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731 PMID: 24077179
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关键词: FLI 06, FLI 06 supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Other, Signaling, Translocation, 5172, Tocris Bioscience
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