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FMF-04-159-R

Cat. No. 7159 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
化学名： N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FMF-04-159-R

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC50 = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

技术数据 for FMF-04-159-R

分子量 685.02
公式 C28H32Cl3N7O5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2741262-15-5
InChI Key CPSBAEQKXVXCRQ-UHFFFAOYSA-N
Smiles CN(CCCC(NC1=CC=CC(S(=O)(N2CCC(NC(C3=NNC=C3NC(C4=C(C=C(C=C4Cl)Cl)Cl)=O)=O)CC2)=O)=C1)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FMF-04-159-R

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 68.5 100
ethanol 34.25 50

制备储备液 for FMF-04-159-R

以下数据基于产品分子量 685.02。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.3 mL 14.6 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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参考文献 for FMF-04-159-R

参考文献是支持产品生物活性的出版物。

Ferguson et al (2019) Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity. Cell Chem.Biol. 26 804 PMID: 30930164

If you know of a relevant reference for FMF-04-159-R, please let us know.

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关键词: FMF-04-159-R, FMF-04-159-R supplier, cyclin, dependent, kinase, Cdk, CDK, inhibitors, inhibits, CDK14, CDK16, CDK2, CDK17, CDK18, TAIRE, family, kinases, reversible, CDK5, Subfamily, 7159, Tocris Bioscience

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