FPL 64176

Cat. No. 1403 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent Ca_V1.x activator

化学名： 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for FPL 64176

FPL 64176 is a potent activator of L-type Ca²⁺ channels (EC₅₀ = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.

技术数据 for FPL 64176

分子量	347.41
公式	C₂₂H₂₁NO₃
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	120934-96-5
PubChem ID	3423
InChI Key	MDMWHKZANMNXTF-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C1C(=O)C1=CC=CC=C1CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FPL 64176

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	8.69	25
	DMSO	17.37	50

制备储备液 for FPL 64176

以下数据基于产品分子量 347.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.76 mL	28.78 mL	57.57 mL
2.5 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
25 mM	0.12 mL	0.58 mL	1.15 mL

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产品说明书 for FPL 64176

分析证书/产品说明书

化学品安全技术说明书

参考文献 for FPL 64176

参考文献是支持产品生物活性的出版物。

Baxter et al (1993) Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J.Med.Chem. 36 2739 PMID: 7692047

Rampe et al (1993) Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca⁺⁺ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 265 1125 PMID: 7685384

Zheng et al (1991) Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca²⁺ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 40 734 PMID: 1719369

If you know of a relevant reference for FPL 64176, please let us know.

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关键词: FPL 64176, FPL 64176 supplier, Potent, activator, Ca2+, channels, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, FPL64176, Cav1.x, 1403, Tocris Bioscience