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说明： Induces ferroptosis; inhibits FSP1
化学名： 3-(4-Bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole
纯度： ≥98% (HPLC)
生物活性 for FSEN 1
FSEN 1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor (IC50 = 313 nM). FSEN 1 sensitizes lung cancer cells and organoids to ferroptosis (EC50 = 69 nM) through inhibition of FSP1. Inhibits FSP1 CoQ1 oxidoreductase activity (IC50 = 688 nM).
技术数据 for FSEN 1
| 分子量 | 484.42 |
| 公式 | C22H22BrN5OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 862808-01-3 |
| PubChem ID | 22583648 |
| InChI Key | JGXIXBKKDUNARN-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for FSEN 1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.69 | 20 |
制备储备液 for FSEN 1
以下数据基于产品分子量 484.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.32 mL | 51.61 mL | 103.22 mL |
| 1 mM | 2.06 mL | 10.32 mL | 20.64 mL |
| 2 mM | 1.03 mL | 5.16 mL | 10.32 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
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产品说明书 for FSEN 1
参考文献 for FSEN 1
参考文献是支持产品生物活性的出版物。
Hendricks et al (2023) Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem.Biol. 30 1090 PMID: 37178691
If you know of a relevant reference for FSEN 1, please let us know.
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关键词: FSEN 1, FSEN 1 supplier, FSEN1, ferroptosis, sensititizer, 1, suppressor, protein, FSP1, CoQ1, lung, cancer, Ferroptosis, 7941, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Pathways for FSEN 1
