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Submit ReviewFumitremorgin C
说明： Inhibitor of BCRP-mediated multidrug resistance
化学名： (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
纯度： ≥98% (HPLC)
生物活性 for Fumitremorgin C
Fumitremorgin C is a chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.
技术数据 for Fumitremorgin C
| 分子量 | 379.45 |
| 公式 | C22H25N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 118974-02-0 |
| PubChem ID | 403923 |
| InChI Key | DBEYVIGIPJSTOR-FHWLQOOXSA-N |
| Smiles | O=[C@@]3N5[C@@H](CCC5)C(N([C@H]3C4)[C@@H](/C=C(C)/C)C2=C4C1=CC=C(OC)C=C1N2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Fumitremorgin C
参考文献 for Fumitremorgin C
参考文献是支持产品生物活性的出版物。
Rabindran et al (2000) Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60 PMID: 10646850
Rabindran et al (1998) Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58 5850 PMID: 9865745
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关键词: Fumitremorgin C, Fumitremorgin C supplier, mycotoxins, chemosensitisers, chemosensitizers, chemosensitizing, chemosensitising, BCRP, breast, cancer, resistance, proteins, reverses, multidrug, MDR, FumitremorginC, Multidrug, Transporters, 2876, Tocris Bioscience
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