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G6PDi 1

Cat. No. 7561 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor
化学名： 4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for G6PDi 1

G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC50 = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines in vitro. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.

许可信息

Sold under license from Princeton University

技术数据 for G6PDi 1

分子量 284.34
公式 C14H12N4OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2457232-14-1
PubChem ID 145998284
InChI Key USWCHVCZOGGQQA-UHFFFAOYSA-N
Smiles O=C1CCCCC2=NC(NC3=CSC(C#N)=C3)=NC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for G6PDi 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.43 100

制备储备液 for G6PDi 1

以下数据基于产品分子量 284.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.58 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for G6PDi 1

参考文献是支持产品生物活性的出版物。

Ghergurovich et al (2020) A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat.Chem.Biol. 16 731 PMID: 32393898

If you know of a relevant reference for G6PDi 1, please let us know.

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关键词: G6PDi 1, G6PDi 1 supplier, G6PDi1, glucose-6-phosphate, dehydrogenase, G6PD, inhibitors, inhibits, potent, reversible, Other, Dehydrogenases, 7561, Tocris Bioscience

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