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Submit ReviewGabapentin
说明： Increases brain GABA; anticonvulsant
化学名： 1-(Aminomethyl)cyclohexaneacetic acid
纯度： ≥99%
生物活性 for Gabapentin
Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for Gabapentin
| 分子量 | 171.24 |
| 公式 | C9H17NO2 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% |
| CAS Number | 60142-96-3 |
| PubChem ID | 3446 |
| InChI Key | UGJMXCAKCUNAIE-UHFFFAOYSA-N |
| Smiles | NCC1(CC(O)=O)CCCCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Gabapentin
参考文献 for Gabapentin
参考文献是支持产品生物活性的出版物。
Fink et al (2000) Inhibition of Ca2+ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900 PMID: 10864898
Taylor et al (1998) A summary of mechanistic hypotheses of gabap. pharmacology. Epilepsy Res. 29 233 PMID: 9551785
Timmerman et al (2000) A microdialysis study on the mechanism of action of gabap. Eur.J.Pharmacol. 398 53 PMID: 10856447
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818
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1 篇 Gabapentin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Gabapentin 的部分引用包括：
Sant'Anna et al (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci 6 26955 PMID: 27230787
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.