Gadolinium chloride

Name: Gadolinium chloride
Brand: Tocris Bioscience
SKU: 4741
Rating: 5 (1 reviews)

Cat. No. 4741 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Stretch-activated calcium channel blocker; calcium-sensing receptor agonist

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Gadolinium chloride

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.

技术数据 for Gadolinium chloride

分子量	263.61
公式	GdCl₃
储存	Desiccate at RT
CAS Number	10138-52-0
PubChem ID	61486
InChI Key	MEANOSLIBWSCIT-UHFFFAOYSA-K
Smiles	Cl[Gd](Cl)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gadolinium chloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	26.36	100

制备储备液 for Gadolinium chloride

以下数据基于产品分子量 263.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.79 mL	18.97 mL	37.93 mL
5 mM	0.76 mL	3.79 mL	7.59 mL
10 mM	0.38 mL	1.9 mL	3.79 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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产品说明书 for Gadolinium chloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Gadolinium chloride

参考文献是支持产品生物活性的出版物。

Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺ and cAMP. Nature 492 123 PMID: 23143333

Del Favero et al (2012) The stretch-activated channel blocker Gd³⁺ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474

Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548

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关键词: Gadolinium chloride, Gadolinium chloride supplier, CaSR, calcium, sensing, receptors, agonists, stretch, activated, channels, blockers, TRP, TRPML, Other, Calcium, Channels, Calcium-Sensing, Receptor, 4741, Tocris Bioscience

6 篇 Gadolinium chloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Gadolinium chloride 的部分引用包括：

Dela Paz (2018) Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun 497 220 PMID: 29428723

Mark S et al (2021) Augmented KCa2.3 Channel Feedback Regulation of Oxytocin Stimulated Uterine Strips from Nonpregnant Mice. Int J Mol Sci 22 PMID: 34948381

François et al (2022) Role of Ion Channels in the Maintenance of Sperm Motility and Swimming Behavior in a Marine Teleost. Int J Mol Sci 23 PMID: 36292967

Yin et al (2017) Quantum dots modulate intracellular Ca²⁺level in lung epithelial cells. Int J Nanomedicine 12 2781 PMID: 28435258

Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. J Immunol 7 PMID: 25873305

Ina et al (2020) Binding Dynamics of α-Actinin-4 in Dependence of Actin Cortex Tension. Biophys J 119 1091-1107 PMID: 32853564

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