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Galangin

Cat. No. 6494 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6494 has been discontinued.

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说明： TRPC5 inhibitor; also induces autophagy
化学名： 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Galangin

Galangin is a TRPC5 inhibitor. Inhibits Ca2+ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy. Also displays antiviral activity against HSV-1, coxsackie B virus type 1, adenovirus type 31 and reovirus.

技术数据 for Galangin

分子量 270.24
公式 C15H10O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 548-83-4
PubChem ID 5281616
InChI Key VCCRNZQBSJXYJD-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(C3=CC=CC=C3)=C(C2=O)O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Galangin

参考文献是支持产品生物活性的出版物。

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375

Chen et al (2017) Galangin reduces the loss of DArgic neurons in an LPS-evoked model of Parkinson's disease in rats. Int.J.Mol.Sci. 19 PMID: 29267220

So et al (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr.Cancer. 26 167 PMID: 8875554

Wen et al (2012) Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 89 247 PMID: 22507894

Meyer et al (1997) Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J.Ethnopharmacol. 56 165 PMID: 9174978

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关键词: Galangin, Galangin supplier, Galangin, TRPC5, inhibitors, autophagy, inducers, flavonoids, inhibits, induces, Autophagy, TRPC, Non-selective, Antivirals, 6494, Tocris Bioscience

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