Galanthamine hydrobromide

Cat. No. 0686 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cholinesterase inhibitor

化学名： 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Galanthamine hydrobromide

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC₅₀ = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

技术数据 for Galanthamine hydrobromide

分子量	368.27
公式	C₁₇H₂₁NO₃.HBr
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	1953-04-4
PubChem ID	121587
InChI Key	QORVDGQLPPAFRS-XPSHAMGMSA-N
Smiles	O[C@H]1C=C[C@]([C@]2=C(O4)C(OC)=CC=C2CN(CC3)C)3[C@@H]4C1.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Galanthamine hydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	7.37	20 温和加热
	water	7.37	20

制备储备液 for Galanthamine hydrobromide

以下数据基于产品分子量 368.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	13.58 mL	67.88 mL	135.77 mL
1 mM	2.72 mL	13.58 mL	27.15 mL
2 mM	1.36 mL	6.79 mL	13.58 mL
10 mM	0.27 mL	1.36 mL	2.72 mL

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产品说明书 for Galanthamine hydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Galanthamine hydrobromide

参考文献是支持产品生物活性的出版物。

Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103 PMID: 14654102

Capsoni et al (2002) Nerve growth factor and galant. ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432 PMID: 12205295

Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113 PMID: 8604434

Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024 PMID: 12649296

Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129 PMID: 2626444

If you know of a relevant reference for Galanthamine hydrobromide, please let us know.

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关键词: Galanthamine hydrobromide, Galanthamine hydrobromide supplier, Galanthamine, Galantamine, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR, Cholinesterases, (Non-selective), 0686, Tocris Bioscience

1 篇 Galanthamine hydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Galanthamine hydrobromide 的部分引用包括：

Souza et al (2012) Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome. Sci Rep 1 137 PMID: 22355654

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