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Submit ReviewGallein is an inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
分子量 | 364.31 |
公式 | C20H12O7 |
储存 | Store at -20°C |
纯度 | ≥97% |
CAS Number | 2103-64-2 |
PubChem ID | 73685 |
InChI Key | PHLYOKFVXIVOJC-UHFFFAOYSA-N |
Smiles | OC1=CC=C(C(C(C=CC=C5)=C5C(O4)=O)4C(C=CC(O)=C3O)=C3O2)C2=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 27.32 | 75 | |
ethanol | 3.64 | 10 |
以下数据基于产品分子量 364.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.75 mM | 3.66 mL | 18.3 mL | 36.6 mL |
3.75 mM | 0.73 mL | 3.66 mL | 7.32 mL |
7.5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
37.5 mM | 0.07 mL | 0.37 mL | 0.73 mL |
参考文献是支持产品生物活性的出版物。
Lehmann et al (2008) Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 73 410 PMID: 18006643
Ukhanov et al (2011) Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 31 273 PMID: 21209212
If you know of a relevant reference for Gallein, please let us know.
关键词: Gallein, Gallein supplier, inhibitors, inhibits, betagamma, signaling, G, Proteins, Heterotrimeric, G-protein, GTPases, 3090, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Gallein 的部分引用包括:
Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326
Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688
Liu et al (2016) Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Scientific Reports 6 33614 PMID: 27647162
Stott et al (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proc Natl Acad Sci U S A 112 6497 PMID: 25941381
López-Cotarelo et al (2015) A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. Inflamm Res 290 827 PMID: 25425646
Sanz et al (2014) Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation. PLoS One 9 e85110 PMID: 24416348
Foster et al (2014) Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB J 28 4497 PMID: 25002118
Zhao et al (2018) Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2. Molecules 23 PMID: 30424024
Travers et al (2017) Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. J Am Coll Cardiol 70 958 PMID: 28818206
Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546
Chung et al (2015) Albumin-associated free fatty acids induce macropinocytosis in podocytes. J Clin Invest 125 2307 PMID: 25915582
Sikka et al (2014) Melanopsin mediates light-dependent relaxation in blood vessels. J Biol Chem 111 17977 PMID: 25404319
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
Cervantes-Villagrana et al (2019) Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal 13 179 PMID: 30612298
Cameron (2017) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu. Sci Rep 7 10578 PMID: 28874749
Ukhanov et al (2011) Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J Neurosci 31 273 PMID: 21209212
Weber (2017) Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS One 12 e0172491 PMID: 28273117
Salgado-Pabón et al (2013) Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio 4 PMID: 23963178
Ahmadiantehrani and Ron (2013) DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem PMID: 23373701
Meens et al (2012) G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. Br J Pharmacol 166 297 PMID: 22074193
Breshears et al (2012) A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem 287 32578 PMID: 22833676
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In-vivo (mouse) and in-vitro (HEK cells) experiments
Gallein is not easy to dissolve in solution, to do that is better dissolve gallein in a small quantity of DMSO and then reach your final concentration using Saline. Total DMSO% in the final volume should be no more then 0.5%.