Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGalnon
说明： Non-selective galanin receptor agonist
化学名： 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
生物活性 for Galnon
Galnon is a novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
技术数据 for Galnon
| 分子量 | 678.83 |
| 公式 | C40H46N4O6 |
| 序列 |
AK (Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran) |
| 储存 | Desiccate at -20°C |
| CAS Number | 475115-35-6 |
| PubChem ID | 5311268 |
| InChI Key | IKNOZZKXIDSTRN-PXLJZGITSA-N |
| Smiles | CC1=CC(=O)OC2=C1C=CC(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1CCCCC1)NC(=O)OCC1C3=CC=CC=C3C3=C1C=CC=C3)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Galnon
参考文献 for Galnon
参考文献是支持产品生物活性的出版物。
Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55 PMID: 15003717
Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136 PMID: 12011470
Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874 PMID: 15647369
Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on Ins release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213 PMID: 15670772
按产品操作查看相关产品
关键词: Galnon, Galnon supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, 2085, Tocris Bioscience
1 篇 Galnon 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Galnon 的部分引用包括：
Einstein et al (2013) Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and mor. conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci 37 1541 PMID: 23387435
Galnon 的评论
目前没有该产品的评论。 Be the first to review Galnon and earn rewards!
Have you used Galnon?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.