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Submit ReviewGanaxolone
说明： Potent positive allosteric modulator of GABAA receptors
别名： CCD 1042
化学名： (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
生物活性 for Ganaxolone
Ganaxolone is a potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
技术数据 for Ganaxolone
| 分子量 | 332.53 |
| 公式 | C22H36O2 |
| 储存 | Store at +4°C |
| CAS Number | 38398-32-2 |
| PubChem ID | 6918305 |
| InChI Key | PGTVWKLGGCQMBR-FLBATMFCSA-N |
| Smiles | O[C@]1(C)CC[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@](C)=O)([H])C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ganaxolone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 3.33 | 10 温和加热 | |
| ethanol | 6.65 | 20 |
制备储备液 for Ganaxolone
以下数据基于产品分子量 332.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.04 mL | 75.18 mL | 150.36 mL |
| 1 mM | 3.01 mL | 15.04 mL | 30.07 mL |
| 2 mM | 1.5 mL | 7.52 mL | 15.04 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
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产品说明书 for Ganaxolone
参考文献 for Ganaxolone
参考文献是支持产品生物活性的出版物。
Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284 PMID: 9067315
Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169 PMID: 10625734
Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336 PMID: 10928304
If you know of a relevant reference for Ganaxolone, please let us know.
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关键词: Ganaxolone, Ganaxolone supplier, Potent, positive, allosteric, modulators, GABAA, receptors, Receptors, CCD1042, PAM, CCD, 1042, 2531, Tocris Bioscience
1 篇 Ganaxolone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ganaxolone 的部分引用包括：
Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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