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Gap 27

Cat. No. 1476 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective gap junction blocker
纯度： ≥95% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Gap 27

Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

技术数据 for Gap 27

分子量 1304.55
公式 C60H101N15O17
序列 SRPTEKTIFII
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 198284-64-9
PubChem ID 9920128
InChI Key SXRAPDIXXYFGJG-MDAHIHQXSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gap 27

溶解性 Soluble to 1 mg/ml in water

产品说明书 for Gap 27

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Gap 27

参考文献是支持产品生物活性的出版物。

Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561 PMID: 9508817

Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147 PMID: 10898726

Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1 PMID: 11522590

If you know of a relevant reference for Gap 27, please let us know.

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关键词: Gap 27, Gap 27 supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27, 1476, Tocris Bioscience

2 篇 Gap 27 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Gap 27 的部分引用包括：

Westphalen et al (2014) Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506 503 PMID: 24463523

Dosch et al (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife 8 PMID: 30735126

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