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Gap19

Cat. No. 5353 5 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Cx43 hemichannel blocker
纯度： ≥95% (HPLC)
说明书
引用文献 (5)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Gap19

Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

技术数据 for Gap19

分子量 1161.45
公式 C55H96N14O13
序列 KQIEIKKFK
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1507930-57-5
PubChem ID 91691126
InChI Key IEAKEKFIXUZWEH-PKMKMBMKSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gap19

溶解性 Soluble to 2 mg/ml in water

产品说明书 for Gap19

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Gap19

参考文献是支持产品生物活性的出版物。

Boengler et al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4 PMID: 23760924

Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8 PMID: 25374505

If you know of a relevant reference for Gap19, please let us know.

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关键词: Gap19, Gap19 supplier, Selective, Cx43, hemichannels, blockers, blocks, Connexin43, Panx-1, gap, junctions, Gap, Channels, 5353, Tocris Bioscience

5 篇 Gap19 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Gap19 的部分引用包括：

Miyuki et al (2023) The Involvement of Cx43 in JNK1/2-Mediated Endothelial Mechanotransduction and Human Plaque Progression. Int J Mol Sci 24 PMID: 36674690

Chen et al (2018) Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway. Front Cell Neurosci 12 372 PMID: 30386214

Juan V et al (2021) Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? Front Pharmacol 12 613449 PMID: 33867979

Best et al (2019) Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. Nat Commun 10 4190 PMID: 31519898

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