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Submit ReviewγDGG
说明： Broad spectrum glutamatergic antagonist
化学名： γ-D-Glutamylglycine
纯度： ≥99% (HPLC)
生物活性 for γDGG
γDGG is a broad spectrum glutamate receptor antagonist.
技术数据 for γDGG
| 分子量 | 204.18 |
| 公式 | C7H12N2O5 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 6729-55-1 |
| PubChem ID | 6604701 |
| InChI Key | ACIJGUBIMXQCMF-SCSAIBSYSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CCC(NCC(O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for γDGG
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. NaOH | 100 | ||
| water | 20.42 | 100 温和加热 |
制备储备液 for γDGG
以下数据基于产品分子量 204.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.9 mL | 24.49 mL | 48.98 mL |
| 5 mM | 0.98 mL | 4.9 mL | 9.8 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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产品说明书 for γDGG
参考文献 for γDGG
参考文献是支持产品生物活性的出版物。
Aksenov et al (2005) Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classical conditioned eyeblinks and neuronal activity. J.Neurophysiol. 93 44 PMID: 15331619
Jones et al (1984) Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience 13 573 PMID: 6392929
If you know of a relevant reference for γDGG, please let us know.
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关键词: gammaDGG, gammaDGG supplier, Broad, spectrum, glutamate, receptor, antagonists, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, γDGG, gammaDGG, Non-selective, Glutamate, mGlu, 0112, Tocris Bioscience
3 篇 γDGG 的引用文献
引用文献是使用了 Tocris 产品的出版物。 γDGG 的部分引用包括：
Chen et al (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci 33 8336 PMID: 23658173
Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron 63 482 PMID: 19709630
Grueter et al (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28 9261 PMID: 18784306
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gamma-DGG impact on whole-cell response of cerebellar neuron.
By
Anonymous on 06/07/2019
分析类型： Ex Vivo
种属： Rat
细胞系/组织： Cerebellum
Being added to perfusion solution at 0.5 mM concentration, gamma-DGG decreased electrical response amplitudes of pharmacologically isolated glutamate receptors in cerebellar neuron, and increased their paired-pulse ratio.
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