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Submit ReviewGLP-1 (9-36) amide
说明： Metabolite of GLP-1-(7-36) (Cat. No. 2082)
别名： Glucagon-like peptide 1 (9-36) amide
纯度： ≥95% (HPLC)
生物活性 for GLP-1 (9-36) amide
GLP-1 (9-36) amide is a N-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) (Cat. No. 2082) formed by dipeptidyl peptidase-IV cleavage. Acts as an antagonist at the human GLP-1 receptor. Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent.
技术数据 for GLP-1 (9-36) amide
| 分子量 | 3089.44 |
| 公式 | C140H214N36O43 |
| 序列 |
EGTFTSDVSSYLEGQAAKEFIAWLVKGR (Modification: Arg-28 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 161748-29-4 |
| PubChem ID | 90488821 |
| InChI Key | WPNGPBPCQMDAAD-WRFZDFFOSA-N |
| Smiles | [H]N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GLP-1 (9-36) amide
| 溶解性 | Soluble to 2 mg/ml in 0.025% acetic acid |
产品说明书 for GLP-1 (9-36) amide
参考文献 for GLP-1 (9-36) amide
参考文献是支持产品生物活性的出版物。
Knudsen and Pridal (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur.J.Pharmacol. 318 429 PMID: 9016935
Elahi et al (2008) GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide is a glucoregulatory peptide. Obesity 16 1501 PMID: 18421270
Deacon et al (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J.Clin.Endocrinol.Met. 80 952
If you know of a relevant reference for GLP-1 (9-36) amide, please let us know.
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关键词: GLP-1 (9-36) amide, GLP-1 (9-36) amide supplier, Metabolite, GLP-1-7-36, GLP1, Receptors, Glucagon-Like, Peptide, 1, Glucagon, like, peptide1, (9-36), amide, diabetes, Glucagon-like, peptide, 3266, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
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