Glucagon-like peptide 1 (7-36) amide (human, rat)

Cat. No. 2082 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent insulinotropic peptide

别名： GLP-1 (7-36) amide

纯度： ≥95% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

Glucagon-like peptide 1 (7-36) amide (human, rat) is a potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (K_d = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.

技术数据

分子量	3297.67
公式	C₁₄₉H₂₂₆N₄₀O₄₅
序列	HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR (Modifications: Arg-30 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	107444-51-9
PubChem ID	16133831
InChI Key	DTHNMHAUYICORS-KTKZVXAJSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶解性	Soluble to 1 mg/ml in water

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参考文献

参考文献是支持产品生物活性的出版物。

Goke and Conlon (1988) Receptors for glucagon-like peptide-1(7-37) amide on rat Insoma-derived cells. J.Endocrinol. 116 357 PMID: 2832504

Turton et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69 PMID: 8538742

Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717 PMID: 11124853

Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881 PMID: 12183643

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关键词: Glucagon-like peptide 1 (7-36) amide (human, rat), Glucagon-like peptide 1 (7-36) amide (human, rat) supplier, Potent, insulinotropic, peptide, GLP-1, Receptors, Glucagon-Like, Peptide, 1, Glucagon-like, peptide1, (7-36), amide, (human, rat), GLP1(7-36), 2082, Tocris Bioscience

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