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Gly MCA

Cat. No. 6669 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6669 has been discontinued.

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说明： FXR antagonist; selectively active in intestines; orally bioavailable
化学名： N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Gly MCA

Gly MCA is a farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metabolic syndrome in obese mice. Orally bioavailable.

技术数据 for Gly MCA

分子量 465.62
公式 C26H43NO6
储存 Store at -20°C
CAS Number 66225-78-3
PubChem ID 131675923
InChI Key ZQYUKJFJPJDMMR-DLUUSONCSA-N
Smiles [H][C@]1([C@@H](CCC(NCC(O)=O)=O)C)CC[C@]2([C@@]3([C@H]([C@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)O)[H])[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Gly MCA

参考文献是支持产品生物活性的出版物。

Jiang et al (2015) Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat.Commun. 6 10166 PMID: 26670557

Wahlström et al (2016) Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24 41 PMID: 27320064

Clemmensen et al (2017) Gut-brain cross-talk in metabolic control. Cell 168 758 PMID: 28235194

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关键词: Gly MCA, Gly MCA supplier, GlyMCA, farnesoid, X, receptor, FXR, antagonists, antagonsim, obesity, insulin, resistance, diabetes, orally, bioavailable, LXR-like, Receptors, 6669, Tocris Bioscience

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