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Submit ReviewGlycine
说明： Endogenous potentiator of NMDA receptors
化学名： Aminoethanoic acid
生物活性 for Glycine
One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.
技术数据 for Glycine
| 分子量 | 75.07 |
| 公式 | C2H5NO2 |
| 储存 | Store at RT |
| CAS Number | 56-40-6 |
| PubChem ID | 750 |
| InChI Key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
| Smiles | NCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Glycine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 100 |
制备储备液 for Glycine
以下数据基于产品分子量 75.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 13.32 mL | 66.6 mL | 133.21 mL |
| 5 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 10 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 50 mM | 0.27 mL | 1.33 mL | 2.66 mL |
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产品说明书 for Glycine
参考文献 for Glycine
参考文献是支持产品生物活性的出版物。
Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 458 PMID: 1722365
Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 5 318 PMID: 7850154
Ascher and Johnson (1989) The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 109
Johnson and Ascher (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325 529
If you know of a relevant reference for Glycine, please let us know.
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关键词: Glycine, Glycine supplier, Endogenous, glycine, receptor, agonists, potentiator, co-transmitter, GlyR, Glycine, Receptors, Glutamate, NMDA, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0219, Tocris Bioscience
4 篇 Glycine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Glycine 的部分引用包括：
Hangen et al (2018) Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR. Cell Rep 24 1001 PMID: 30044968
Sivakumaran et al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. Front Cell Neurosci 35 8291 PMID: 26019342
Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324 PMID: 18990687
Kaushal and Schlichter (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28 2221 PMID: 18305255
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Glycine 的评论
平均评分: 5 (Based on 1 Review.)
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Use of glycine as NMDA receptor co-agonist.
By
Anonymous on 10/19/2019
种属： Human
Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response in outside-out patched excised from hippocampal neurons. Glycine displayed a clear co-agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.
For experiments with NMDA receptors use of D-Serine is sometimes better.
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