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Submit ReviewGLYX 13
说明： NMDA partial agonist; acts at the glycine site
别名： Rapastinel
纯度： ≥95% (HPLC)
生物活性 for GLYX 13
GLYX 13 is a NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Also promotes VGF and BDNF release and increases ERK/mTOR signaling. Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.
技术数据 for GLYX 13
| 分子量 | 413.47 |
| 公式 | C18H31N5O6 |
| 序列 |
TPPT (Modifications: Thr-4 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 117928-94-6 |
| PubChem ID | 14539800 |
| InChI Key | GIBQQARAXHVEGD-BSOLPCOYSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GLYX 13
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for GLYX 13
参考文献 for GLYX 13
参考文献是支持产品生物活性的出版物。
Moskal et al (2005) GLYX-13: A monoclonal antibody-derived peptide that acts as an N-MthD.-aspartate receptor modulator. Neuropharmacology 49 1077 PMID: 16051282
Zhang et al (2008) A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. 55 1238 PMID: 18796308
Wood et al (2008) Antinociceptive action of GLYX-13: a N-MthD.-aspartate receptor glycine site partial agonist. Neuroreport. 19 1059 PMID: 18580579
Burgdorf et al (2009) The N-MthD.-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol.Aging 32 698 PMID: 19446371
Shen et al (2022) ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Transl.Psychiatry 12 522 PMID: 36550125
If you know of a relevant reference for GLYX 13, please let us know.
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关键词: GLYX 13, GLYX 13 supplier, NMDA, receptor, partial, agonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, GLYX13, psychoplastogen, Rapastinel, 3406, Tocris Bioscience
1 篇 GLYX 13 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GLYX 13 的部分引用包括：
Shen et al (2022) ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Transl.Psychiatry 12 522 PMID: 36550125
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