Goserelin acetate

Name: Goserelin acetate
Brand: Tocris Bioscience
SKU: 3592

Cat. No. 3592 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3592 has been discontinued.

View all Gonadotropin-Releasing Hormone Receptors products.

说明： GnRH receptor agonist

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Goserelin acetate

Goserelin acetate is a synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

技术数据 for Goserelin acetate

分子量	1269.42
公式	C₅₉H₈₄N₁₈O₁₄
序列	XHWSYSLRP (Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)
储存	Desiccate at -20°C
CAS Number	145781-92-6
PubChem ID	90488862
InChI Key	BLCLNMBMMGCOAS-JFBCNRKLSA-N
Smiles	[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O)C(=O)C1CCC(=O)N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Goserelin acetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Goserelin acetate

参考文献是支持产品生物活性的出版物。

Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091 PMID: 8033142

Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059 PMID: 8616851

Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254

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关键词: Goserelin acetate, Goserelin acetate supplier, GnRH, receptor, antagonists, Receptors, gonadotropin, Gonadotrophin-Releasing, Hormone, ICI118630, chemotherapeutics, 3592, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Goserelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

篇 Goserelin acetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Goserelin acetate 的引用文献。