GR 144053 trihydrochloride

Cat. No. 1263 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Glycoprotein IIb/IIIa (integrin α_IIbβ₃) receptor antagonist. Antithrombotic

化学名： 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GR 144053 trihydrochloride

GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC₅₀ = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo.

技术数据 for GR 144053 trihydrochloride

分子量	454.83
公式	C₁₈H₂₇N₅O₂.3HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	1215333-48-4
PubChem ID	107895
InChI Key	GFZHNFOGCMEYTA-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.NC(=N)C1=CC=C(C=C1)N1CCN(CC1)C1CCN(CC(O)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GR 144053 trihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	45.48	100

制备储备液 for GR 144053 trihydrochloride

以下数据基于产品分子量 454.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.2 mL	10.99 mL	21.99 mL
5 mM	0.44 mL	2.2 mL	4.4 mL
10 mM	0.22 mL	1.1 mL	2.2 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for GR 144053 trihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GR 144053 trihydrochloride

参考文献是支持产品生物活性的出版物。

Eldred et al (1994) Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 37 3882 PMID: 7966149

Matsuno et al (1997) GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 122 1099 PMID: 9480031

Matsuno et al (1999) Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 127 1129 PMID: 10455258

If you know of a relevant reference for GR 144053 trihydrochloride, please let us know.

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关键词: GR 144053 trihydrochloride, GR 144053 trihydrochloride supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, antagonists, Antithrombotic, receptor, Adhesion, Molecules, Integrin, Receptors, GR144053, trihydrochloride, Cell, Integrins, 1263, Tocris Bioscience

1 篇 GR 144053 trihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GR 144053 trihydrochloride 的部分引用包括：

Pavlou et al (2023) CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci.Rep. 13 3934 PMID: 36894612

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