GR 32191 hydrochloride

Name: GR 32191 hydrochloride
Brand: Tocris Bioscience
SKU: 1958

Cat. No. 1958 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1958 has been discontinued.

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说明： Potent thromboxane A₂/TP receptor antagonist

别名： Vapiprost

化学名： (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for GR 32191 hydrochloride

Potent thromboxane A₂ (TP) receptor antagonist. Inhibits platelet aggregation (pA₂ ~ 8.3) and relaxes vascular and airway smooth muscle (pA₂ = 7.9 - 10.3).

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

技术数据 for GR 32191 hydrochloride

分子量	514.1
公式	C₃₀H₃₉NO₄.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	85505-64-2
Smiles	Cl[H].O[C@H]1C[C@H](OCC2=CC=C(C=C2)C2=CC=CC=C2)[C@H](CC\C=C/CCC(O)=O)[C@H]1N1CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for GR 32191 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GR 32191 hydrochloride

参考文献是支持产品生物活性的出版物。

Lumley et al (1989) GR32191, a highly potent and specific thromboxane A₂ receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br.J.Pharmacol. 97 783 PMID: 2527074

Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361

Takahara et al (1990) The response to thromboxane A₂ analogues in human platelets. J.Biol.Chem. 265 6836 PMID: 2139029

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篇 GR 32191 hydrochloride 的引用文献

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