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Submit ReviewGRK2i
Discontinued Product
3594 has been discontinued.
View all Heterotrimeric G-protein GTPases products.
说明： GRK2 inhibitory polypeptide; Gβ/γ antagonist
纯度： ≥95% (HPLC)
生物活性 for GRK2i
GRK2i is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
技术数据 for GRK2i
| 分子量 | 3484.08 |
| 公式 | C153H256N50O41S |
| 序列 | WKKELRDAYREAQQLVQRVPKMKNKPRS |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 148505-03-7 |
| PubChem ID | 90488863 |
| InChI Key | QYWJBYYWQATYFS-ICUWLHSYSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GRK2i
参考文献 for GRK2i
参考文献是支持产品生物活性的出版物。
Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J.Biol.Chem. 269 6193 PMID: 8119963
Macrez et al (1997) A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J.Biol.Chem. 272 23180 PMID: 9287322
Dang et al (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322 PMID: 19279269
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关键词: GRK2i, GRK2i supplier, GRK, inhibitory, polypeptide, Gbg, antagonists, Gβγ, Gbetagamma, G, protein, heterotrimeric, Heterotrimeric, G-protein, GTPases, 3594, Tocris Bioscience
4 篇 GRK2i 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GRK2i 的部分引用包括：
Kirill A et al (2019) Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors. Neuropsychopharmacology 44 642-653 PMID: 30546127
Sierra-Fonseca et al (2014) Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci 15 132 PMID: 25552352
Stott et al (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Apoptosis 112 6497 PMID: 25941381
Lutz et al (2021) Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Rep 34 108718 PMID: 33535037
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