GSK 4716

Name: GSK 4716
Brand: Tocris Bioscience
SKU: 3075

Cat. No. 3075 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3075 has been discontinued.

View all Estrogen and Related Receptors products.

说明： Selective ERRγ and ERRβ agonist

别名： GW4716

化学名： 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for GSK 4716

GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and the classical estrogen receptors.

技术数据 for GSK 4716

分子量	282.34
公式	C₁₇H₁₈N₂O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	101574-65-6
PubChem ID	5331325
InChI Key	IKPPIUNQWSRCOZ-WOJGMQOQSA-N
Smiles	OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for GSK 4716

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GSK 4716

参考文献是支持产品生物活性的出版物。

Zuercher et al (2005) Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J.Med.Chem. 48 3107 PMID: 15857113

Ariazi and Jordan (2006) Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr.Top.Med.Chem. 6 203 PMID: 16515477

Wang et al (2006) X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem. 281 37773 PMID: 16990259

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Estrogen and Related Receptors

关键词: GSK 4716, GSK 4716 supplier, Selective, ERRγ, ERRgamma, ERRβ, ERRbeta, agonists, Estrogen, related, Receptors, GSK4716, GW4716, and, Related, 3075, Tocris Bioscience

1 篇 GSK 4716 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 4716 的部分引用包括：

Weber et al (2014) Bisphenol A exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78 50 PMID: 25424546

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Pathways for GSK 4716

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.