主页 / 药理学 / Enzymes / Kinases / Receptor Interacting Protein Kinase Family / Receptor Interacting Protein Kinases / Receptor Interacting Protein Kinase Inhibitors / GSK 583

GSK 583

Cat. No. 6480 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent RIPK2 inhibitor; orally bioavailable and cell permeable
化学名： 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 583

GSK 583 is a potent RIPK2 inhibitor (IC50 values are 2 and 5 nM at rat and human kinases, respectively). Displays selectivity for RIP2K over p38α, VEGFR2 and a panel of 300 kinases. Exhibits some inhibition at BRK and Aurora A. Also displays similar binding affinity, but no detectable functional activity at RIP3. Active in vivo. Moderately orally bioavailable and cell permeable.

技术数据 for GSK 583

分子量 398.45
公式 C20H19FN4O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1346547-00-9
PubChem ID 67469084
InChI Key XLOGLWKOHPIJLV-UHFFFAOYSA-N
Smiles CC(C)(S(=O)(C1=CC2=C(N=CC=C2NC3=NNC4=CC=C(C=C34)F)C=C1)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 583

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.84 100
ethanol 7.97 20

制备储备液 for GSK 583

以下数据基于产品分子量 398.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for GSK 583

参考文献是支持产品生物活性的出版物。

Haile et al (2016) The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 kinase. J.Med.Chem. 59 4867 PMID: 27109867

If you know of a relevant reference for GSK 583, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Receptor Interacting Protein Kinase Inhibitors

关键词: GSK 583, GSK 583 supplier, GSK583, Potent, RIP2, kinase, inhibitors, inhibits, oral, bioavailability, cell, permeable, receptor-interacting, protein, 1, RIP, Kinases, 6480, Tocris Bioscience

1 篇 GSK 583 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 583 的部分引用包括：

Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839

您是否知道使用了 Tocris GSK 583 的优秀论文？ 请告知我们.

GSK 583 的评论

目前没有该产品的评论。 Be the first to review GSK 583 and earn rewards!

Have you used GSK 583?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review