GsMTx4

Name: GsMTx4
Brand: Tocris Bioscience
SKU: 4912
Rating: 4 (1 reviews)

Cat. No. 4912 10 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

纯度： ≥95% (HPLC)

说明书

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GsMTx4

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.

许可信息

Sold under license from The Research Foundation of The State University of New York

技术数据 for GsMTx4

分子量	4095.86
公式	C₁₈₅H₂₇₃N₄₉O₄₅S₆
序列	GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Disulfide bridges: 2-17, 9-23, 16-30), Phe-34 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1209500-46-8
PubChem ID	90488987
InChI Key	WVDNTWXIIKNMHY-UHFFFAOYSA-N
Smiles	[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GsMTx4

溶解性	Soluble to 1 mg/ml in water

产品说明书 for GsMTx4

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GsMTx4

参考文献是支持产品生物活性的出版物。

Bowman et al (2007) Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 49 249 PMID: 17157345

Suchyna et al (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J.Gen.Physiol. 115 583 PMID: 10779316

Drew et al (2007) High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One 2 e515 PMID: 17565368

Bae et al (2011) The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry 50 6295 PMID: 21696149

Beaulieu-Laroche et al (2020) TACAN is an ion channel involved in sensing mechanical pain. Cell 180 956 PMID: 32084332

Acheva et al (2021) Adipokine leptin co-operates with mechanosensitive Ca^{2 +}-Channels and triggers actomyosin-mediated motility of breast epithelial cells. Front.Cell.Dev.Biol. 8 607038 PMID: 33490070

Velasco-Estevez et al (2020) Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia 68 356 PMID: 31596529

Pathak et al (2014) Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc.Natl.Acad.Sci.U.S.A. 111 16148 PMID: 25349416

If you know of a relevant reference for GsMTx4, please let us know.

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