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Submit ReviewGuanfacine hydrochloride
说明： α2A agonist
化学名： [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Guanfacine hydrochloride
Guanfacine hydrochloride is a selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors.
技术数据 for Guanfacine hydrochloride
| 分子量 | 282.56 |
| 公式 | C9H9Cl2N3O.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 29110-48-3 |
| PubChem ID | 71401 |
| InChI Key | DGFYECXYGUIODH-UHFFFAOYSA-N |
| Smiles | Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Guanfacine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 28.26 | 100 | |
| DMSO | 28.26 | 100 |
制备储备液 for Guanfacine hydrochloride
以下数据基于产品分子量 282.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.7 mL | 35.39 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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产品说明书 for Guanfacine hydrochloride
参考文献 for Guanfacine hydrochloride
参考文献是支持产品生物活性的出版物。
Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48 PMID: 9103479
Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α2A -selective compound. Eur.J.Pharmacol. 202 235 PMID: 1666366
Merck Index 12 4590
If you know of a relevant reference for Guanfacine hydrochloride, please let us know.
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关键词: Guanfacine hydrochloride, Guanfacine hydrochloride supplier, α2A-adrenoceptor, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-adrenergic, α2a-adrenergic, alpha2a-adrenergic, agonists, Receptors, Adrenergic, Alpha-2, 1030, Tocris Bioscience
4 篇 Guanfacine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Guanfacine hydrochloride 的部分引用包括：
Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Pharmacol Res Perspect 32 14489 PMID: 23077035
An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523 PMID: 25393479
Shields et al (2009) alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience 163 339 PMID: 19527774
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.