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Submit ReviewGue 1654
Discontinued Product
4742 has been discontinued.
View all Heterotrimeric G-protein GTPases products.
说明： Selective inhibitor of OXE-R Gβ/γ signaling
化学名： N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide
纯度： ≥97% (HPLC)
生物活性 for Gue 1654
Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
技术数据 for Gue 1654
| 分子量 | 447.6 |
| 公式 | C23H17N3OS3 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 397290-30-1 |
| PubChem ID | 5066134 |
| InChI Key | UFOBDFMYJABXGK-UHFFFAOYSA-N |
| Smiles | O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)NC(S3)=NC1=C3C(SC(SC)=N2)=C2C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Gue 1654
参考文献 for Gue 1654
参考文献是支持产品生物活性的出版物。
Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631 PMID: 22634634
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关键词: Gue 1654, Gue 1654 supplier, Gue1654, OXE-R, modulators, inhibitors, inhibits, selective, beta, gamma, β, γ, signalling, signaling, heterotrimeric, G-proteins, oxeiocosanoid, receptors, Heterotrimeric, G-protein, GTPases, Leukotriene, and, Related, Receptors, 4742, Tocris Bioscience
1 篇 Gue 1654 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Gue 1654 的部分引用包括：
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
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