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GW 4869

Cat. No. 6741 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor
化学名： 3,3'-(1,4-Phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-propenamide] ditrifluoroacetate
纯度： ≥90% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GW 4869

GW 4869 is a selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (IC50 = 1 μM). Exhibits selectivity for neutral sphingomyelinase over acid sphingomyelinase (a-SMase) at concentrations up to 150 μM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 μM. Blocks exosome biogenesis. Inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells. Reverses hypoxia-induced pulmonary vasoconstriction in rats. Neuroprotective.

技术数据 for GW 4869

分子量 732.64
公式 C30H28N6O2.2CF3COOH
储存 Store at -20°C
纯度 ≥90% (HPLC)
InChI Key OVUGNZQTDFNYTB-CLEIDKRQSA-N
Smiles O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C3=NCCN3)C=C2)=O)NC4=CC=C(C5=NCCN5)C=C4.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GW 4869

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.47 2

制备储备液 for GW 4869

以下数据基于产品分子量 732.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.02 mM 68.25 mL 341.23 mL 682.46 mL
0.1 mM 13.65 mL 68.25 mL 136.49 mL
0.2 mM 6.82 mL 34.12 mL 68.25 mL
1 mM 1.36 mL 6.82 mL 13.65 mL

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产品说明书 for GW 4869

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for GW 4869

参考文献是支持产品生物活性的出版物。

Essandoh et al (2015) Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochim.Biophys.Acta 1852 2362 PMID: 26300484

Tabatadze et al (2010) Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice. J.Neurosci.Res. 88 2940 PMID: 20629193

Figuera-Losada et al (2015) Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One 10 e0124481 PMID: 26010541

Lallemand et al (2018) NSMase2 (type 2-neutral sphingomyelinase) deficiency or inhibition by GW4869 reduces inflammation and atherosclerosis in apoe -/- mice. Arterioscler.Thromb.Vasc.Biol. 38 1479 PMID: 29794115

If you know of a relevant reference for GW 4869, please let us know.

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关键词: GW 4869, GW 4869 supplier, 6823-69-4, GW4869, N-SMase, neutral, sphingomyelinase, inhibitors, inhibits, potent, cell, permeable, sphyngomyelin, phosphodiesterase, 2, selective, Other, Hydrolases, 6741, Tocris Bioscience

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