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Submit ReviewGYKI 47261 dihydrochloride
说明： Non-competitive AMPA antagonist
化学名： 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-benzeneamine dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for GYKI 47261 dihydrochloride
GYKI 47261 dihydrochloride is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.
技术数据 for GYKI 47261 dihydrochloride
| 分子量 | 395.71 |
| 公式 | C18H15ClN4.2HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1217049-32-5 |
| PubChem ID | 46861544 |
| InChI Key | HUNSEMNKAFDVDI-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C3C(C(C4=CC=C(N)C=C4)=NN2C(C3)=NC(C)=C2)=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GYKI 47261 dihydrochloride
参考文献 for GYKI 47261 dihydrochloride
参考文献是支持产品生物活性的出版物。
Abraham et al (2000) New non competitive AMPA antagonists. Bioorg.Med.Chem. 8 2127 PMID: 11003158
Bibbiani et al (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 196 422 PMID: 16203001
Solyo (2001) Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie 25 S62
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关键词: GYKI 47261 dihydrochloride, GYKI 47261 dihydrochloride supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, GYKI47261, dihydrochloride, 3099, Tocris Bioscience
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