Halofuginone hydrobromide

Cat. No. 1993 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity competitive prolyl-tRNA synthetase inhibitor

化学名： (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Halofuginone hydrobromide

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (K_i = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

技术数据 for Halofuginone hydrobromide

分子量	495.59
公式	C₁₆H₁₇BrClN₃O₃.HBr
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	64924-67-0
PubChem ID	400771
InChI Key	SJUWEPZBTXEUMU-LDXVYITESA-N
Smiles	BrC1=CC2=C(C(N(CC(C[C@@H]3[C@H](O)CCCN3)=O)C=N2)=O)C=C1Cl.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Halofuginone hydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	49.56	100

制备储备液 for Halofuginone hydrobromide

以下数据基于产品分子量 495.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.4 mL	2.02 mL	4.04 mL
10 mM	0.2 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for Halofuginone hydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Halofuginone hydrobromide

参考文献是支持产品生物活性的出版物。

Anderson et al (1979) Analysis of the anti-coccidial drug, halofunginone, in chicken feed using gas-liquid chromatography and high-performance liquid chromatography. J.Chromatogr. 168 471 PMID: 570196

Elkin et al (1999) Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clin.Cancer.Res. 5 1982 PMID: 10473075

Keller et al (2012) Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 8 311 PMID: 22327401

If you know of a relevant reference for Halofuginone hydrobromide, please let us know.

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关键词: Halofuginone hydrobromide, Halofuginone hydrobromide supplier, High, affinity, competitive, prolyl-tRNA, synthetase, inhibitors, inhibits, metastasis, MMP2, matrix, metalloprotease, autoimmunity, antiparasitic, Other, Synthases/Synthetases, DNA,, RNA, and, Protein, Synthesis, 1993, Tocris Bioscience

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