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Submit ReviewHEAT hydrochloride
说明： Highly selective α1 antagonist
别名： BE 2254
化学名： 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride
纯度： ≥98% (HPLC)
生物活性 for HEAT hydrochloride
HEAT hydrochloride is a very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.
技术数据 for HEAT hydrochloride
| 分子量 | 331.84 |
| 公式 | C19H21NO2.HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 30007-39-7 |
| PubChem ID | 34771 |
| InChI Key | VCZXZECZIRGUCZ-UHFFFAOYSA-N |
| Smiles | Cl.OC1=CC=C(CCNCC2CCC3=CC=CC=C3C2=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for HEAT hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.18 | 100 |
制备储备液 for HEAT hydrochloride
以下数据基于产品分子量 331.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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产品说明书 for HEAT hydrochloride
参考文献 for HEAT hydrochloride
参考文献是支持产品生物活性的出版物。
Baumgarten et al (1972) Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats. Naunyn Schmiedebergs Arch.Pharmacol. 274 375 PMID: 4404780
Williams et al (1978) Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes. J.Pharm.Pharmacol. 30 390 PMID: 26778
If you know of a relevant reference for HEAT hydrochloride, please let us know.
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关键词: HEAT hydrochloride, HEAT hydrochloride supplier, selective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, BE2254, 2-{[b-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone, hydrochloride, BE, 2254, Adrenergic, Alpha-1, 0535, Tocris Bioscience
3 篇 HEAT hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HEAT hydrochloride 的部分引用包括：
Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648 PMID: 21571945
Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Circ Res 24 7745 PMID: 15342742
Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.