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Submit ReviewHexamethonium bromide
Discontinued Product
4111 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
说明： Non-competitive nAChR antagonist
化学名： N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
生物活性 for Hexamethonium bromide
Hexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
技术数据 for Hexamethonium bromide
| 分子量 | 362.19 |
| 公式 | C12H30Br2N2 |
| 储存 | Desiccate at RT |
| CAS Number | 55-97-0 |
| PubChem ID | 5938 |
| InChI Key | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| Smiles | C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Hexamethonium bromide
参考文献 for Hexamethonium bromide
参考文献是支持产品生物活性的出版物。
Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297 PMID: 18264777
Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332
关键词: Hexamethonium bromide, Hexamethonium bromide supplier, Hexamethonium, Br, nicotinic, receptor, blocker, ganglion, nAChR, antagonist, Nicotinic, Receptors, (Non-selective), 4111, Tocris Bioscience
5 篇 Hexamethonium bromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Hexamethonium bromide 的部分引用包括：
Xin-Ming et al (2019) Identifying roles for peptidergic signaling in mice. Proc Natl Acad Sci U S A 116 20169-20179 PMID: 31455734
Tomomi et al (2022) Patch clamp recording from bipolar cells in the wholemount mouse retina. STAR Protoc 3 101482 PMID: 35769922
Robert G et al (2021) Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina. Cell Rep 37 110106 PMID: 34910920
Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771
Bernhard et al (2021) GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. Elife 10 PMID: 33913808
Hexamethonium bromide 的评论
平均评分: 5 (Based on 1 Review.)
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Nicotinic blocker for decreasing stimulated dopamine release.
By
Anonymous on 05/15/2018
分析类型： Ex Vivo
种属： Mouse
This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.